Labelled with care – radiosynthesis
Institute of Isotopes Co., Ltd. offers C-14, C-13 or H-3 labelling services for organic compounds widely used in metabolism (ADME) or e-fate studies during agrochemical studies or pharmaceutical research.
Our Synthesis Business Unit provides a wide selection of labelled pesticides, herbicides, fungicides and other bioactive compounds that play significant role in the registration of agrochemicals. Our GMP Laboratory also enables us to provide key labelled compounds for clinical research serving the Pharma Industry.
Given our solid experience in radiosynthesis our partners also trust us to develop unique methods and perform complex and challenging custom synthesis tasks. Beside our catalogue products we are looking forward to unique requests to support our customers.
Our dedicated and experienced team, delivering excellence in chemistry, supports the global agribusiness industry by providing radiolabelled test items for various purposes. 14C radiolabelled compounds are the essential tool whether you are in the development phase for a new active ingredient, or conducting regulatory studies (environmental fate and behaviour, metabolism, residue, eco-toxicological etc..).
We are uniquely specialised in 14C labelled agrochemicals, the detailed list of our catalogue product is available below:
| Acephate, [S-methyl-14C] | CC-368 |
| Acetamiprid, [pyridyl-2,6-14C] | CC-701 |
| Alachlor, [methoxy-14C] | CC-309 |
| Aldicarb, [i-butyl-14C] | CC-326 |
| Ametryn, [ring-U-14C] | CC-270 |
| Amicarbazone, [1,2,4-triazole 3-14C] | CC-477 |
| Asulam, [ring-U-14C] | CC-315 |
| Atrazine, [ring-U-14C] | CC-298 |
| Azocyclotin, [cyclohexyl-1-14C] | CC-402 |
| Azoxystrobin, [2-cyanophenyl ring-U-14C] | CC-570 |
| Benfuracarb, [isopropyl-2-14C] | CC-370 |
| Benfuracarb, [phenyl ring-U-14C] | CC-371 |
| Bentazone, [carbonyl-14C] | CC-328 |
| Bentazone, [ring-U-14C] | CC-589 |
| Bensulfuron-methyl, [phenyl-U-14C] | CC-722 |
| Bensulfuron-methyl, [pyrimidine-2-14C] | CC-720 |
| Benzyladenine, [8-14C] | CC-451 |
| Benzyladenine, [phenyl-U-14C] | CC-450 |
| Bifenthrin, [benzyl ring-U-14C] | CC-350 |
| Bifenthrin, [cyclopropane-1-14C] | CC-351 |
| Bromoxynil octanoate, [cyano-14C] | CC-625 |
| Bromoxynil octanoate, [ring-U-14C] | CC-333 |
| Bupirimate, [pyrimidine-2-14C] | CC-626 |
| Cadusafos, [sec-butyl-1-14C] | CC-373 |
| Captan, [carboximide-14C] | CC-653 |
| Carbaryl, [ring-1-14C] | CC-255 |
| Carbendazim, [imidazol-2-14C] | CC-305 |
| Carbofuran, [(2,2-dimethyl,3)-14C] | CC-239 |
| Carbofuran, [phenyl ring-U-14C] | CC-339 |
| Chlorfenvinphos, [ethyl-1-14C] | CC-242 |
| Chloridazon, [phenyl-U-14C] | CC-654 |
| Chlorotoluron, [ring-U-14C] | CC-558 |
| Chlorpropham, [ring-U-14C] | CC-482 |
| Chlorpyrifos, [ethyl-1-14C] | CC-243 |
| Chlorpyrifos, [pyridine 2,6-14C] | CC-498 |
| Clodinafop-propargyl, [phenyl ring-U-14C] | CC-421 |
| Clodinafop-propargyl, [pyridyl-2,6-14C] | CC-424 |
| Clofentezine, [tetrazine-3-14C] | CC-690 |
| Clomazone, [phenyl ring-U-14C] | CC-618 |
| Coumaphos, [coumarin-4-14C] | CC-253 |
| Cumyluron, [chlorophenyl ring-U-14C] | CC-746 |
| Cumyluron, [phenyl ring-U-14C] | CC-745 |
| Cyhexatin, [cyclohexyl-1-14C] | CC-308 |
| Beta-cypermethrin, [benzyl-7-14C] | CC-329 |
| Beta-cypermethrin, [cyano-14C] | CC-447 |
| Beta-cypermethrin, [cyclopropane-1-14C] | CC-446 |
| Beta-cypermethrin, [benzyl ring-U-14C] | CC-445 |
| Beta-cypermethrin, [phenyl ring-U-14C] | CC-369 |
| Cypermethrin, [benzyl-7-14C] | CC-261 |
| Cypermethrin, [carboxyl-14C] | CC-266 |
| Cypermethrin, [cyano-14C] | CC-265 |
| Cypermethrin, [cyclopropane-1-14C] | CC-267 |
| Cypermethrin, [phenyl ring-14C] | CC-413 |
| Cymoxanil, [acetyl-2-14C] | CC-444 |
| Cymoxanil, [cyano-14C] | CC-696 |
| Cyprodinil, [phenyl ring-U-14C] | CC-616 |
| 2,4-D, [carboxyl-14C] | CC-294 |
| 2,4-D, [ring-U-14C] | CC-292 |
| 2,4-DB, [ring-U-14C] | CC-367 |
| 2,4-D dimethylammonium salt, [ring-U-14C] | CC-715 |
| Cyromazine, [ring-U-14C] | CC-714 |
| DDE, [ring-U-14C] | CC-257 |
| DDT, [ring-U-14C] | CC-256 |
| Deltamethrin, [benzyl-7-14C] | CC-259 |
| Deltamethrin, [benzyl-ring-U-14C] | CC-560 |
| Deltamethrin, [cyano-14C] | CC-262 |
| Desmedipham, [phenyl ring-U-14C] | CC-619 |
| Diazinon, [pyrimidinyl-6-14C] | CC-318 |
| Dicamba, [carboxyl-14C] | CC-355 |
| Dicamba, [ring-U-14C] | CC-492 |
| Dichlobenil, [cyano-14C] | CC-376 |
| Dichlobenil, [ring-U-14C] | CC-377 |
| Dichlorprop, [ring-U-14C] | CC-354 |
| Dichlorvos, [methyl-14C] | CC-341 |
| Diclofop acid, [2,4-dichlorophenoxy ring-U-14C] | CC-541 |
| Diclofop-methyl, [1,4-dioxyphenyl ring-U-14C] | CC-621 |
| Diclofop-methyl, [2,4-dichlorophenoxy ring-U-14C] | CC-540 |
| Dicofol, [ring-U-14C] | CC-314 |
| Difenoconazole, [triazole-U-14C] | CC-456 |
| Diflovidazin, [tetrazine-3-14C] | CC-581 |
| Diflovidazin, [tetrazine-6-14C] | CC-582 |
| Dimethoate, [O-methyl-14C] | CC-306 |
| Dimethoate, [carbonyl-14C] | CC-336 |
| Dimethomorph, [4-chlorophenyl ring-U-14C] | CC-610 |
| Dioxathion, [ethyl-1-14C] | CC-244 |
| Diquat dibromide monohydrate, [14C] | CC-681 |
| Dithianon, [5-14C] | CC-735 |
| Diuron, [carbonyl-14C] | CC-297 |
| Diuron, [ring-U-14C] | CC-325 |
| Endosulfan, [2,3-14C] | CC-258 |
| Epoxiconazole, [epoxy-2-14C] | CC-487 |
| EPTC, [carbonyl-14C] | CC-295 |
| EPTC, [propyl-1-14C] | CC-453 |
| Esprocarb, [ring-U-14C] | CC-551 |
| Ethephon, [U-14C] | CC-316 |
| Ethirimol, [pyrimidine-2-14C] | CC-680 |
| Ethofumesate, [benzene ring-U-14C] | CC-613 |
| Etofenprox, [3-phenoxybenzyl-7-14C] | CC-496 |
| Etofenprox, [propyl-2-14C] | CC-674 |
| Fenamiphos, [phenyl ring-U-14C] | CC-647 |
| Fenarimol, [carbinol-14C] | CC-407 |
| Fenarimol, [4-chlorophenyl ring-U-14C] | CC-408 |
| Fenobucarb, [ring-U-14C] | CC-238 |
| Fenpropidin, [propyl-3-14C] | CC-652 |
| Ferbam, [carbamate-14C] | CC-467 |
| Florasulam, [2-14C] | CC-635 |
| Florasulam, [2′,6′-difluorophenyl ring-U-14C] | CC-634 |
| Fluazinam, [pyridil-2,6-14C] | CC-648 |
| Fluazinam, [phenyl-U-14C] | CC-688 |
| Flufenacet, [phenyl ring-U-14C] | CC-556 |
| Fluometuron, [ring-U-14C] | CC-719 |
| Flurochloridon, [phenyl ring-U-14C] | CC-615 |
| Fluroxypyr-meptyl, [acetyl-1-14C] | CC-645 |
| Flusulfamide, [2’-chloro-4’-nitrophenyl ring-U-14C] | CC-378 |
| Flusulfamide, [4-chloro-3-trifluoromethylphenyl ring-U-14C] | CC-379 |
| Folpet, [phenyl ring-U-14C] | CC-428 |
| Forchlorfenuron, [phenyl ring-U-14C] | CC-380 |
| Forchlorfenuron, [pyridine 2,6-14C] | CC-397 |
| Glyphosate, [glycine-2-14C] | CC-311 |
| Glyphosate, [P-methylene-14C] | CC-293 |
| Hexachlorobenzene, [U-14C] | CC-357 |
| Hexazinone, [triazine-6-14C] | CC-307 |
| Hexythiazox, [cyclohexyl-U-14C] | CC-452 |
| Hexythiazox, [1,3-thiazolidine-14C] | CC-691 |
| Hexythiazox, [phenyl ring-U-14C] | CC-729 |
| IM-1-5, [pyridyl-2,6-14C] | CC-708 |
| Imazalil, [phenyl-U-14C] | CC-702 |
| Imidacloprid, [imidazolidine ring-2-14C] | CC-327 |
| Imidacloprid, [pyridyl-2,6-14C] | CC-640 |
| Iminoctadine triacetate, [guanidine-14C] | CC-404 |
| Iminoctadine triacetate, [octyl-1,8-14C] | CC-405 |
| Iodocarb, [butyl-1-14C] | CC-643 |
| Iodocarb, [carbamate-14C] | CC-489 |
| Iodocarb, [carbamate-14C, butyl-1-14C] | CC-734 |
| Iodosulfuron-methyl-sodium, [phenyl-U-14C] | CC-717 |
| Iodosulfuron-methyl-sodium, [triazine-U-14C] | CC-716 |
| Iprodione, [phenyl-U-14C] | CC-697 |
| Isoproturon, [ring-U-14C] | CC-337 |
| Isoxathion, [isoxazole-5-14C] | CC-614 |
| Lactofen, [2-nitrophenyl ring-U-14C] | CC-395 |
| Lambda-Cyhalothrin, [phenoxy-U-14C] | CC-707 |
| Lambda-Cyhalothrin, [cyano-14C] | CC-703 |
| Lenacil, [pyrimidine-4,6-14C] | CC-381 |
| Lindane, [ring-U-14C] | CC-330 |
| Linuron, [carbonyl-14C] | CC-296 |
| Linuron, [ring-U-14C] | CC-310 |
| Malathion, [succinyl-2,3-14C] | CC-246 |
| Mancozeb, [ethylene-1,2-14C] | CC-304 |
| Maneb, [ethylene-1,2-14C] | CC-276 |
| MCPA, [carboxyl-14C] | CC-414 |
| MCPA, [ring-U-14C] | CC-382 |
| MCPA-2-ethylhexyl ester, [ring-U-14C] | CC-724 |
| Mecoprop, [ring-U-14C] | CC-401 |
| Mefenacet, [aniline ring-U-14C] | CC-383 |
| Mesosulfuron-methyl, [pyrimidine-2-14C] | CC-728 |
| Mesotrione, [1,3-cyclohexanedione-2-14C] | CC-638 |
| Mesotrione, [1,3-cyclohexanedione-1(3)-14C] | CC-675 |
| Mesotrione, [phenyl-U-14C] | CC-700 |
| rac-Metalaxyl acid, [ring-U-14C] | CC-534 |
| Metalaxyl, [ring-U-14C] | CC-400 |
| Metalaxyl-M, [ring-U-14C] | CC-672 |
| rac-Metamifop, [2-fluor-phenyl ring-U-14C] | CC-545 |
| rac-Metamifop, [6-chloro-2-benzoxazolyl benzene ring-U-14C] | CC-546 |
| Metamitron, [phenyl ring-U-14C] | CC-409 |
| Metazachlor, [phenyl-U-14C] | CC-571 |
| Metconazole, [1,2,4-triazole-U-14C] | CC-721 |
| Methabenzthiazuron, [benzene ring-U-14C] | CC-466 |
| Methamidophos, [S-methyl-14C] | CC-254 |
| Metholachlor, [ring-U-14C] | CC-726 |
| Metholachlor ESA, [ring-U-14C] | CC-622 |
| Methomyl, [carbonyl-14C] | CC-287 |
| Methoprene, [5-14C] | CC-420 |
| Metribuzin, [ring-6-14C] | CC-320 |
| Metsulfuron-methyl,[triazinyl-2-14C] | CC-360 |
| Monocrotophos, [O-methyl-14C] | CC-250 |
| MSMA, [14C] | CC-271 |
| rac-Napropamide, [1-naphthyloxy-1-14C] | CC-685 |
| Nicosulfuron, [pyrimidine-2-14C] | CC-692 |
| Oxamyl, [carbamoyl-14C] | CC-331 |
| Oxasulfuron, [phenyl ring-U-14C] | CC-650 |
| Oxasulfuron, [pyrimidine-2-14C] | CC-651 |
| Paraoxon, [ethyl-1-14C , ring-U-14C] | CC-385 |
| Parathion, [ring-U-14C] | CC-247 |
| Parathion, [ethyl-1-14C, ring-U-14C] | CC-396 |
| Parathion-methyl, [ring-U-14C] | CC-353 |
| Pentachlorophenol, [U-14C] | CC-274 |
| Permethrin, [phenoxy ring-U-14C] | CC-386 |
| Phenmedipham, [3-methyl-phenyl ring-U-14C] | CC-620 |
| Phenthoate, [ring-U-14C] | CC-576 |
| Phosmet, [phthalimide-1,3-14C] | CC-730 |
| Pirimiphos-methyl, [pyrimidinyl-2-14C] | CC-248 |
| Pyrimethanil, [pyrimidinyl-2-14C] | CC-689 |
| Prochloraz, [phenyl ring-U-14C] | CC-269 |
| Prochloraz zinc complex, [phenyl ring-U-14C] | CC-639 |
| Propanil, [ring-U-14C] | CC-575 |
| Propiconazole, [dioxolane-4-14C] | CC-323 |
| Propiconazole, [benzene-U-14C] | CC-268 |
| Propiconazole, [triazol ring-U-14C] | CC-387 |
| Propisochlor, [2-chloroacetyl 1-14C] | CC-417 |
| Propisochlor, [ring-U-14C] | CC-416 |
| Propyzamide, [carboxyl-14C] | CC-486 |
| Prosulfocarb, [ring-U-14C] | CC-356 |
| Prosulfocarb sulfoxide, [ring-U-14C] | CC-443 |
| Prothioconazole, [phenyl-U-14C] | CC-709 |
| Prothioconazole-desthio, [1,2,4-triazole-U-14C] | CC-711 |
| Pyributicarb, [pyridyl-2,6-14C] | CC-362 |
| Pyributicarb, [phenyl-U-14C] | CC-363 |
| Pyridaphenthion, [pyridazinyl-4,5-14C] | CC-389 |
| Quinmerac, [benzene ring-U-14C] | CC-655 |
| SDDC, [carbamate-14C] | CC-442 |
| SDEDC, [carbamate-14C] | CC-536 |
| Simazine, [ring-U-14C] | CC-249 |
| Sulcotrione, [1,3-cyclohexanedione-2-14C] | CC-557 |
| Sulcotrione, [1,3-cyclohexanedione-1(3)-14C] | CC-623 |
| Tau-fluvalinate, [phenoxy ring-U-14C] | CC-649 |
| Tebuconazole, [phenyl ring-U-14C] | CC-390 |
| Tebuconazole, [triazole ring-U-14C] | CC-459 |
| Tebuthiuron, [ring-5-14C] | CC-272 |
| Tefluthrin, [benzyl-7-14C] | CC-713 |
| Terbufos, [O-ethyl-1-14C] | CC-321 |
| Terbuthylazine, [ring-U-14C] | CC-437 |
| Terbutryn, [ring-U-14C] | CC-448 |
| Tetradifon, [4-chlorophenyl-U-14C] | CC-661 |
| Thiophanate-methyl, [ring-U-14C] | CC-572 |
| Thiram, [carbamate-14C] | CC-441 |
| Tri-allate, [allyl-1-14C] | CC-364 |
| Tribenuron-methyl, [phenyl ring-U-14C] | CC-484 |
| Tribenuron-methyl, [triazine ring-U-14C] | CC-485 |
| Vinclozolin, [phenyl ring-U-14C] | CC-394 |
| Zineb, [ethylene-1,2-14C] | CC-277 |
| Ziram, [carbamate-14C] | CC-324 |
| Ziram, [methyl-14C] | CC-352 |
14C radiolabelled compounds are necessary tools in ADME studies during clinical, preclinical phase and in discovery investigations. We offer our radiosynthesis expertise providing key active ingredients with specific labelling positions.
Hydrogen isotope labelling allows for the traceless and direct incorporation of an additional mass or radioactive tag into an organic molecule with almost no changes in its chemical structure, physical properties, or biological activity. Tritium (3H), in particular is widely used, especially in pharmaceutical drug discovery.
Labelling with 13C results in a stable, non-radioactive molecule with higher molecular mass. Required analytical equipment for 13C labelled compound is a mass spectrometer. Since the synthetic protocols for 13C and 14C labelled compounds are similar we can utilize our extensive knowledge on radiosynthesis while offering stable isotopic labelled compound for our customers convenience.
Beside our catalogue products we are looking forward to unique requests to support our customers:
We develop and test new synthetic routes to provide unique radiolabelled compounds with specific labelling positions. Utilizing our know-how in radiosynthesis we offer customised solutions to your requirements, please contact us for a quote custom C-14 radiosynthesis project.
With over 25 years of radioisotope analytical experience, we can provide full analysis to verify the radiolabelled molecule and measure (radio)chemical purity. Utilizing qualified analytical instruments, we ensure the reliability of analytical data:
- Liquid scintillation counters
- Flow through detection: radio and UV
- HPLC: analytical, semi-prep and preparative
- TLC and radio TLC detection
- LC-MS analysis
- NMR analysis (with external partners)
We provide purification services of radioisotope- and stable isotope–labelled compounds. By applying purification methods, such as flash column chromatography, preparative high-performance liquid chromatography (HPLC), and recrystallization in order to obtain the requested purity.
Utilizing our strategic position being connected to the main international network hubs, with over 30 years of experience, a IATA trained logistic staff and international partner network we can arrange door-to-door delivery around the globe.
On long term base we can provide comprehensive service including synthesis, re-purification, and long-term storage of radiolabelled compounds.
Whether you need radiolabelled compounds for use in metabolism studies, for environmental fate studies, or to support your R&D or research program, our company offers customized solutions to your requirements. You might find the requested compound among our catalogue products, or contact us for a custom synthesis project:
There are a number of important factors to consider when ordering labelled compounds. In case you would like to receive a customised price quotation please contact our Sales Team with the following relevant parameters included:
- correct chemical or common name of the compounds (in case of more complicated molecules together with the formula);
- labelling isotope (C-14, H-3) and position of labelling;
- required molar or specific activity;
- required quantity, activity (MBq or mCi);
- required form (net material or a solution – in the latter case the requested solvent and radiochemical concentration; requested packsize);
- requested lead time
To quote C-13 labelled stable compounds please, specify the name of the compound, labelling position, enrichment %, chemical purity, quantity (mg, g).
In case of any further questions please, do not hesitate to contact us.