In Vivo Products for Human Diagnosis and Therapy

(See Product List below)

IZOTOP’s facility licensed for operating at a high level of radioactivity is located near to the Budapest research reactor. The level “A” isotope laboratory includes hot cell lines for the chemical and pharmaceutical processing of radionuclides. In addition, clean-room facilities in the radioactive and non-radioactive zones are available for production of radiopharmaceuticals and cold-kits, respectively. IZOTOP is a licensed company, possessing a GMP Certificate for pharmaceutical preparation as well. IZOTOP is licensed also for manufacturing of active pharmaceutical ingredients as well as investigational products for clinical trials.

Production of Radioisotopes

Radionuclides from neutron irradiation are mainly produced as raw materials for radiopharmaceutical preparations or as radiochemicals. The regularly prepared radioisotopes for in vivo use are ⁹⁰Y, ¹³¹I and ¹⁵³Sm while ¹²⁵I is manufactured for labelling of various tracers used in life sciences or by „in vitro diagnostic products”. Furthermore ¹⁶⁶Ho and ¹⁷⁷Lu are also manufactured for labelling novel compounds. Certain reactor isotopes are available on request from time to time.

In Vivo Radiopharmaceuticals

^99mTc Radiopharmaceutical Kits

Cold kits for ^99mTc-labeling fully meet the clinical requirements for studying renal, bone and hepatobiliary systems. DMSA provides excellent renal imaging as well as a possibility to determine the the functional mass of kidneys. DTPA and EC (Ethylene-L, L-dicysteine) are used for studying the dynamics of the glomerular and tubular function, respectively. DTPA can also be used for liquor circulation studies. MDP is the most commonly used bone-seeking agent. Using IZOTOP’s FYTON kit, the colloid forming under in vivo conditions is suitable for both liver scintigraphy and for the detection of internal bleeding. TECHIDA is available for dynamic studies of the liver cell function and hepatobiliary excretion; PYRON in an agent for labeling red blood cells for blood-pool or spleen scintigraphy.

Palliative Therapy

EDTMP (MULTIBONE) kit is manufactured for labeling either with ⁹⁰Y or with ¹⁵³Sm-precursors to obtain agents for palliative therapy of painful bone metastases.

¹³¹I Radiopharmaceutical

¹³¹I sodium-iodide is formulated in solution and is available as „ThyroTop” capsules.
¹³¹I-MIBG is produced for imaging and the therapeutic treatment of neuroendocrine tumors.

Radiopharmaceutical Products